Human β-secretase (BACE) and BACE inhibitors

被引：140

作者：

John, V

Beck, JP

Bienkowski, MJ

Sinha, S

Heinrikson, RL

机构：

[1] Elan Pharmaceut, San Francisco, CA 94080 USA

[2] Pfizer Corp, Kalamazoo, MI 49007 USA

来源：

关键词：

D O I：

10.1021/jm030247h

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：4625 / 4630

页数：6

共 43 条

[1] The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region
Acquati, F
Accarino, M
Nucci, C
Fumagalli, P
Jovine, L
Ottolenghi, S
Taramelli, R
[J]. FEBS LETTERS, 2000, 468 (01): : 59 - 64
[2] Beck J. P., 2002, [No title captured], Patent No. [WO 02/002520, 02002520]
[3] A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase
Bennett, BD
Denis, P
Haniu, M
Teplow, DB
Kahn, S
Louis, JC
Citron, M
Vassar, R
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) : 37712 - 37717
[4] BHISETTI GR, 2002, Patent No. 0288101
[5] BACE1 is the major β-secretase for generation of Aβ peptides by neurons
Cai, HB
Wang, YS
McCarthy, D
Wen, HJ
Borchelt, DR
Price, DL
Wong, PC
[J]. NATURE NEUROSCIENCE, 2001, 4 (03) : 233 - 234
[6] Biomedicine - A portrait of Alzheimer secretases - New features and familiar faces
Esler, WP
Wolfe, MS
[J]. SCIENCE, 2001, 293 (5534) : 1449 - 1454
[7] Etcheberrigaray R., 2002, Patent, Patent No. [WO. 02/96897, 0296897]
[8] Fang L. Y., 2002, [No title captured], Patent No. [02002505, WO 02/002505]
[9] Fang L. Y., 2002, [No title captured], Patent No. [WO 02/002506, 02002506]
[10] Fisher J. F., 2003, [No title captured], Patent No. [WO 03/029169, 03029169]