A general method for meta and para functionalization of arenes using TMP2Mg•2LiCl

被引：116

作者：

Rohbogner, Christoph J. ^{[1
]}

Clososki, Giuliano C. ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 08期

关键词：

arenes; directed metalation; Grignard reagents; magnesium bisamides; phosphorodiamidates;

D O I：

10.1002/anie.200703382

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Getting directions: The (Me 2N)2P(O)O substituent serves as an effective directing-metalation group in the magnesiation of substituted arenes with TMP2Mg·2 LiCl (see scheme). This reaction can be used to achieve difficult substitution patterens by meta,para or para,meta functionalization. TMP = 2,2,6,6-tetramethylpiperamidyl, NEP = N-ethylpyrrolidone. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1503 / 1507

页数：5

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