Pathophysiology of diabetic nephropathy

被引：41

作者：

Cooper, ME

Gilbert, RE

Epstein, M

机构：

[1] Univ Melbourne, Austin & Repatriat Med Ctr, Dept Med, Heidelberg, Vic 3081, Australia

[2] Univ Miami, Vet Affairs Med Ctr, Nephrol Sect, Miami, FL USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1998年 / 47卷 / 12期

关键词：

D O I：

10.1016/S0026-0495(98)90362-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic nephropathy (DN) is now the commonest cause of end-stage renal failure in the Western world. Recent studies examining the pathogenesis of diabetic complications have focused on the complex interaction between genetic and hemodynamic mechanisms in addition to metabolic factors such as advanced glycation, protein kinase C (PKC) activation, and polyol production. The importance of the various components, particularly with regard to the progression of DN, is currently being explored with the assistance of targeted drug intervention studies. Copyright (C) 1998 by W.B. Saunders Company.

引用

页码：3 / 6

页数：4