Locking the genome: nuclear organization and cell fate

被引：63

作者：

Meister, Peter ^{[1
]}

Mango, Susan E. ^{[2
]}

Gasser, Susan M. ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

[2] Harvard Univ, Dept Mol & Cell Biol, Cambridge, MA 02138 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2011年 / 21卷 / 02期

关键词：

PLURIPOTENT STEM-CELLS; CHROMATIN REMODELING COMPLEX; CAENORHABDITIS-ELEGANS; HETEROCHROMATIN PROTEIN-1; DEVELOPMENTAL PLASTICITY; DNA METHYLATION; REORGANIZATION; INDUCTION; DYNAMICS; DIFFERENTIATION;

D O I：

10.1016/j.gde.2011.01.023

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The differentiation of pluripotent or totipotent cells into various differentiated cell types is accompanied by a restriction of gene expression patterns, alteration in histone and DNA methylation, and changes in the gross nuclear organization of eu- and heterochromatic domains. Several recent studies have coupled genome-wide mapping of histone modifications with changes in gene expression. Other studies have examined changes in the subnuclear positioning of tissue-specific genes upon transcriptional induction or repression. Here we summarize intriguing correlations of the three phenomena, which suggest that in some cases causal relationships may exist.

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页码：167 / 174

页数：8

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