Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus

被引：35

作者：

Lin, Aiqun ^{[1
]}

Lu, Xiaoming ^{[2
]}

Fang, Yuchun ^{[1
]}

Zhu, Tianjiao ^{[1
]}

Gu, Qianqun ^{[1
]}

Zhu, Weiming ^{[1
]}

机构：

[1] Ocean Univ China, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China

[2] E China Normal Univ, Key Lab Brain Funct Genom, MOE & STCSM, Shanghai Inst Brain Funct Genom, Shanghai 200062, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 04期

关键词：

marine-derived fungus; Aspergillus flavus; 5-hydroxy-2-pyrone; cAMP; GPR12;

D O I：

10.1038/ja.2008.36

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated I might be a possible ligand for GPR12.

引用

页码：245 / 249

页数：5

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