High performance liquid chromatography method for the determination of meropenem in human plasma

被引：16

作者：

Farin, D ^{[1
]}

Kitzes-Cohen, R ^{[1
]}

Piva, G ^{[1
]}

Gozlan, I ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Rappaport Fac Med, Carmel Med Ctr, Clin Pharmacol & Infect Dis Unit, IL-34362 Haifa, Israel

来源：

CHROMATOGRAPHIA | 1999年 / 49卷 / 5-6期

关键词：

column liquid chromatography; meropenem in human plasma; solid phase extraction;

D O I：

10.1007/BF02467552

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes an HPLC method for the determination of meropenem in human plasma. The method uses solid phase extraction (SPE) of the samples and has good sensitivity, precision and accuracy. The limit of quantification in plasma samples is 0.02 mu g mL(-1). Calibration curves were linear over a large dynamic range, namely within 0.02-50 mu g mL(-1). The method was applied to the determination of meropenem levels in patients receiving meropenem, as a single dose or at steady state.

引用

页码：253 / 255

页数：3

共 7 条

[1] DETERMINATION OF MEROPENEM IN PLASMA BY HIGHPERFORMANCE LIQUID-CHROMATOGRAPHY AND A MICROBIOLOGICAL METHOD [J].