Platinum(II)-catalyzed cross-coupling of polyfluoroaryl imines

被引：118

作者：

Wang, Tongen ^{[1
]}

Alfonso, Brian J. ^{[1
]}

Love, Jennifer A. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 26期

关键词：

D O I：

10.1021/ol702591b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The introduction of fluorine into an organic molecule imparts unique physicochemical properties. Not surprisingly, fluorine is increasingly incorporated into new drugs and agrochemicals. However, aryl fluoride building blocks are only available through synthesis. The ability to cross-couple polyfluoroaromatics selectively could provide a convenient route to functionalized fluoroaromatics. We report herein the first examples of Pt-catalyzed cross-coupling of aryl fluorides. The methylated products can potentially serve as precursors to a wide range of functionalized fluorinated small molecules.

引用

页码：5629 / 5631

页数：3

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