Glutamate measurement in Parkinson's disease MRS at 3 T field strength

被引：36

作者：

Kickler, Nils ^{[1
,2
]}

Krack, Paul ^{[3
,4
]}

Fraix, Valerie ^{[3
,4
]}

Lebas, Jean-Francois ^{[6
]}

Lamalle, Laurent ^{[1
,2
]}

Durif, Franck ^{[5
]}

Krainik, Alexandre ^{[1
,2
]}

Remy, Chantal ^{[1
,2
]}

Segebarth, Christoph ^{[1
,2
]}

Pollak, Pierre ^{[3
,4
]}

机构：

[1] CHU Grenoble, INSERM, F-38043 Grenoble, France

[2] Univ Grenoble 1, F-38043 Grenoble, France

[3] INSERM, Neurosci Preclin, F-38043 Grenoble, France

[4] Grenoble Univ Hosp, Dept Neurol, F-38043 Grenoble, France

[5] INSERM, Fac Med Pharm, Unit EMI 9904, F-63001 Clermont Ferrand, France

[6] Grenoble Univ Hosp, INSERM, RMN Biomed Unit IRM 3T, IFR 1, F-38043 Grenoble, France

来源：

NMR IN BIOMEDICINE | 2007年 / 20卷 / 08期

关键词：

glutamate; Parkinson's disease; MRS; TE averaged point-resolved spectroscopy (PRESS);

D O I：

10.1002/nbm.1141

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Loss of nigral dopamine neurons in Parkinson's disease induces abnormal activation of glutamate systems in the basal ganglia. The purpose of this study was to assess these changes in the lentiform nucleus using MRS with optimized glutamate sensitivity (TE-averaged method). Ten patients with Parkinson's disease and 10 healthy controls were examined. Compared with healthy controls, no significant differences in glutamate were measured in patients, but a trend to lower total creatine was observed. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

页码：757 / 762

页数：6

共 27 条

[1]

T2 RELAXATION-TIME IN PATIENTS WITH PARKINSONS-DISEASE [J].

ANTONINI, A ;

LEENDERS, KL ;

MEIER, D ;

OERTEL, WH ;

BOESIGER, P ;

ANLIKER, M .

NEUROLOGY, 1993, 43 (04) :697-700

[2]

ANALYSIS OF MACROMOLECULE RESONANCES IN H-1-NMR SPECTRA OF HUMAN BRAIN [J].

BEHAR, KL ;

ROTHMAN, DL ;

SPENCER, DD ;

PETROFF, OAC .

MAGNETIC RESONANCE IN MEDICINE, 1994, 32 (03) :294-302

[3]

The effect of 6-hydroxydopamine lesions on the release of amino acids in the direct and indirect pathways of the basal ganglia: a dual microdialysis probe analysis [J].

Bianchi, L ;

Galeffi, F ;

Bolam, JP ;

Della Corte, L .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (04) :856-868

[4]

Basal ganglia metabolite concentrations in idiopathic Parkinson's disease and multiple system atrophy measured by proton magnetic resonance spectroscopy [J].

Clarke, CE ;

Lowry, M .

EUROPEAN JOURNAL OF NEUROLOGY, 2000, 7 (06) :661-665

[5]

Unchanged basal ganglia N-acetylaspartate and glutamate in idiopathic Parkinson's disease measured by proton magnetic resonance spectroscopy [J].

Clarke, CE ;

Lowry, M ;

Horsman, A .

MOVEMENT DISORDERS, 1997, 12 (03) :297-301

[6]

Adenosine A2A receptor antagonism increases striatal glutamate outflow in dopamine-denervated rats [J].

Corsi, C ;

Pinna, A ;

Gianfriddo, M ;

Melani, A ;

Morelli, M ;

Pedata, F .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 464 (01) :33-38

[7]

High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo [J].

de Graaf, Robin A. ;

Brown, Peter B. ;

McIntyre, Scott ;

Nixon, Terence W. ;

Behar, Kevin L. ;

Rothman, Douglas L. .

MAGNETIC RESONANCE IN MEDICINE, 2006, 56 (02) :386-394

[8]

In vivo neurochemical monitoring and the study of behaviour [J].

Fillenz, M .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 29 (06) :949-962

[9]

Govindaraju V, 2000, NMR BIOMED, V13, P129, DOI 10.1002/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO

[10]

2-V

← 1 2 3 →