High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo

被引：248

作者：

de Graaf, Robin A. ^{[1
]}

Brown, Peter B. ^{[1
]}

McIntyre, Scott ^{[1
]}

Nixon, Terence W. ^{[1
]}

Behar, Kevin L. ^{[1
]}

Rothman, Douglas L. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, MRRC, Dept Diagnost Radiol, New Haven, CT 06520 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 2006年 / 56卷 / 02期

关键词：

water T-1/T-2 relaxation; metabolite T-1/T-2 relaxation; macromolecular T-1/T-2 relaxation; high-field NMR; sensitivity; spectral resolution; brain; DIFFERENT REGIONS; ADIABATIC PULSES; NMR-SPECTROSCOPY; TIMES; MACROMOLECULE; FREQUENCY; ECHO; TEMPERATURE; SUPPRESSION; RESONANCES;

D O I：

10.1002/mrm.20946

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Comprehensive and quantitative measurements of T-1 and T-2 relaxation times of water, metabolites, and macromolecules in rat brain under similar experimental conditions at three high magnetic field strengths (4.0 T, 9.4 T, and 11.7 T) are presented. Water relaxation showed a highly significant increase (T,) and decrease (T-2) with increasing field strength for all nine analyzed brain structures. Similar but less pronounced effects were observed for all metabolites. Macromolecules displayed field-independent T2 relaxation and a strong increase of T, with field strength. Among other features, these data show that while spectral resolution continues to increase with field strength, the absolute signal-to-noise ratio (SNR) in T-1/T-2-based anatomical MRI quickly levels off beyond similar to 7 T and may actually decrease at higher magnetic fields.

引用

页码：386 / 394

页数：9

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