Modified Beer-Lambert law for blood flow

被引：230

作者：

Baker, Wesley B. ^{[1
]}

Parthasarathy, Ashwin B. ^{[1
]}

Busch, David R. ^{[1
,2
]}

Mesquita, Rickson C. ^{[3
]}

Greenberg, Joel H. ^{[4
]}

Yodh, A. G. ^{[1
]}

机构：

[1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 USA

[3] Univ Estadual Campinas, Inst Phys, BR-13083859 Campinas, SP, Brazil

[4] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 11期

基金：

美国国家卫生研究院; 巴西圣保罗研究基金会;

关键词：

NEAR-INFRARED SPECTROSCOPY; DIFFUSE CORRELATION SPECTROSCOPY; TIME-RESOLVED REFLECTANCE; ADULT HEAD MODEL; OPTICAL-PROPERTIES; HUMAN BRAIN; NONINVASIVE MEASUREMENT; ABSORPTION CHANGES; LIGHT-PROPAGATION; OXYGEN-SATURATION;

D O I：

10.1364/BOE.5.004053

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues. (C) 2014 Optical Society of America

引用

页码：4053 / 4075

页数：23

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