Autophagy and vacuole homeostasis - A case for self-degradation?

被引：38

作者：

Mijaljica, Dolibor

Prescott, Mark

Klionsky, Daniel J.

Devenish, Rodney J. ^{[1
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

[2] Monash Univ, ARC Ctr Excellence Struct & Funct Microbial Gen, Clayton, Vic 3800, Australia

[3] Univ Michigan, Dept Mol Cellular & Dev Biol, Inst Life Sci, Ann Arbor, MI 48109 USA

来源：

AUTOPHAGY | 2007年 / 3卷 / 05期

基金：

澳大利亚研究理事会;

关键词：

Atg proteins; autophagy; degradation; membrane; microautophagy; organelle; self-degradation; vacuole; yeast;

D O I：

10.4161/auto.4441

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vacuole of yeast plays an important role in pH- and ion-homeostasis. Another important function of the vacuole, especially during nutrient deprivation, is the degradation of proteins, other macromolecules and organelles. To deliver these components into the vacuolar lumen, specific and sophisticated transport pathways such as autophogy have evolved. This review will first look at autophagy and its relationship to vacuole homeostasis, then move to the topic of vacuole self-degradation and possible reasons for its existence, and close by pointing very briefly to some areas for further research in these topics.

引用

页码：417 / 421

页数：5

共 59 条

[1] Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method [J].