Lung cancer - 9: Molecular biology of lung cancer: clinical implications

被引:87
作者
Fong, KM
Sekido, Y
Gazdar, AF
Minna, JD
机构
[1] Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
[2] Prince Charles Hosp, Brisbane, Qld 4032, Australia
[3] Nagoya Univ, Sch Med, Dept Clin Prevent Med, Showa Ku, Nagoya, Aichi 4668560, Japan
关键词
D O I
10.1136/thorax.58.10.892
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
It has been hypothesised that clinically evident lung cancers have accumulated many different genetic or epigenetic abnormalities in oncogenes and/or tumour suppressor genes. This notion has important clinical ramifications. Recent developments in our knowledge of the molecular biology of lung cancer are reviewed, with particular reference to genetic abnormalities in tumour suppressor gene inactivation and overactivity of growth promoting oncogenes. These changes lead to the "hallmarks of lung cancer''. These hallmarks are the new rational targets for early detection, prevention, and treatment of lung cancer.
引用
收藏
页码:892 / 900
页数:9
相关论文
共 162 条
[1]   Blocking oncogenic Ras signaling for cancer therapy [J].
Adjei, AA .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (14) :1062-1074
[2]  
Agus DB, 2000, SEMIN ONCOL, V27, P53
[3]   Reduced expression of laminin α3 and α5 chains in non-small cell lung cancers [J].
Akashi, T ;
Ito, E ;
Eishi, Y ;
Koike, M ;
Nakamura, K ;
Burgeson, RE .
JAPANESE JOURNAL OF CANCER RESEARCH, 2001, 92 (03) :293-301
[4]   High telomerase activity in primary lung cancers: Association with increased cell proliferation rates and advanced pathologic stage [J].
Albanell, J ;
Lonardo, F ;
Rusch, V ;
Engelhardt, M ;
Langenfeld, J ;
Han, W ;
Klimstra, D ;
Venkatraman, E ;
Moore, MAS ;
Dmitrovsky, E .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (21) :1609-1615
[5]  
Amos CI, 1999, RECENT RESULTS CANC, V151, P3
[6]  
Angeletti CA, 1996, CANCER-AM CANCER SOC, V78, P409, DOI 10.1002/(SICI)1097-0142(19960801)78:3<409::AID-CNCR5>3.0.CO
[7]  
2-E
[8]   Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer [J].
Apolinario, RM ;
vanderValk, P ;
deJong, JS ;
Deville, W ;
vanArkOtte, J ;
Dingemans, AMC ;
vanMourik, JC ;
Postmus, PE ;
Pinedo, HM ;
Giaccone, G .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (06) :2456-2466
[9]   Expression of human telomerase subunit genes in primary lung cancer and its clinical significance [J].
Arinaga, M ;
Shimizu, S ;
Gotoh, K ;
Haruki, N ;
Takahashi, T ;
Takahashi, T ;
Mitsudomi, T .
ANNALS OF THORACIC SURGERY, 2000, 70 (02) :401-405
[10]   Polymorphisms in genes involved in neurotransmission in relation to smoking [J].
Arinami, T ;
Ishiguro, H ;
Onaivi, ES .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 410 (2-3) :215-226