Lung cancer - 9: Molecular biology of lung cancer: clinical implications

被引:87
作者
Fong, KM
Sekido, Y
Gazdar, AF
Minna, JD
机构
[1] Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
[2] Prince Charles Hosp, Brisbane, Qld 4032, Australia
[3] Nagoya Univ, Sch Med, Dept Clin Prevent Med, Showa Ku, Nagoya, Aichi 4668560, Japan
关键词
D O I
10.1136/thorax.58.10.892
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
It has been hypothesised that clinically evident lung cancers have accumulated many different genetic or epigenetic abnormalities in oncogenes and/or tumour suppressor genes. This notion has important clinical ramifications. Recent developments in our knowledge of the molecular biology of lung cancer are reviewed, with particular reference to genetic abnormalities in tumour suppressor gene inactivation and overactivity of growth promoting oncogenes. These changes lead to the "hallmarks of lung cancer''. These hallmarks are the new rational targets for early detection, prevention, and treatment of lung cancer.
引用
收藏
页码:892 / 900
页数:9
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