共 49 条
EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis
被引:108
作者:

Chumley, Michael J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA

Catchpole, Timothy
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA

Silvany, Robert E.
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h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA

Kernie, Steven G.
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h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA

Henkemeyer, Mark
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h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA
机构:
[1] Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA
关键词:
hippocampus;
neurogenesis;
dentate gyrus;
Eph receptor tyrosine kinase;
ephrin ligand;
cell polarity;
D O I:
10.1523/JNEUROSCI.4158-07.2007
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
The adult brain maintains two regions of neurogenesis from which new neurons are born, migrate to their appropriate location, and become incorporated into the circuitry of the CNS. One of these, the subgranular zone of the hippocampal dentate gyrus, is of primary interest because of the role of this region in learning and memory. We show that mice lacking EphB1, and more profoundly EphB1 and EphB2, have significantly fewer neural progenitors in the hippocampus. Furthermore, other aspects of neurogenesis, such as polarity, cell positioning, and proliferation are disrupted in animals lacking the EphB1 receptor or its cognate ephrin-B3 ligand. Our data strongly suggest that EphB1 and ephrin-B3 cooperatively regulate the proliferation and migration of neural progenitors in the hippocampus and should be added to a short list of candidate target molecules for modulating the production and integration of new neurons as a treatment for neurodegenerative diseases or brain injury.
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页码:13481 / 13490
页数:10
相关论文
共 49 条
[11]
The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge
[J].
Dow, L. E.
;
Kauffman, J. S.
;
Caddy, J.
;
Peterson, A. S.
;
Jane, S. M.
;
Russell, S. M.
;
Humbert, P. O.
.
ONCOGENE,
2007, 26 (16)
:2272-2282

Dow, L. E.
论文数: 0 引用数: 0
h-index: 0
机构: Peter MacCallum Canc Ctr, Cell Cycle & Canc Genet Lab, Melbourne, Vic 8006, Australia

Kauffman, J. S.
论文数: 0 引用数: 0
h-index: 0
机构: Peter MacCallum Canc Ctr, Cell Cycle & Canc Genet Lab, Melbourne, Vic 8006, Australia

Caddy, J.
论文数: 0 引用数: 0
h-index: 0
机构: Peter MacCallum Canc Ctr, Cell Cycle & Canc Genet Lab, Melbourne, Vic 8006, Australia

Peterson, A. S.
论文数: 0 引用数: 0
h-index: 0
机构: Peter MacCallum Canc Ctr, Cell Cycle & Canc Genet Lab, Melbourne, Vic 8006, Australia

Jane, S. M.
论文数: 0 引用数: 0
h-index: 0
机构: Peter MacCallum Canc Ctr, Cell Cycle & Canc Genet Lab, Melbourne, Vic 8006, Australia

Russell, S. M.
论文数: 0 引用数: 0
h-index: 0
机构: Peter MacCallum Canc Ctr, Cell Cycle & Canc Genet Lab, Melbourne, Vic 8006, Australia

Humbert, P. O.
论文数: 0 引用数: 0
h-index: 0
机构: Peter MacCallum Canc Ctr, Cell Cycle & Canc Genet Lab, Melbourne, Vic 8006, Australia
[12]
Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development
[J].
Dravis, C
;
Yokoyama, N
;
Chumley, MJ
;
Cowan, CA
;
Silvany, RE
;
Shay, J
;
Baker, LA
;
Henkemeyer, M
.
DEVELOPMENTAL BIOLOGY,
2004, 271 (02)
:272-290

Dravis, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA

Yokoyama, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA

Chumley, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA

Cowan, CA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA

Silvany, RE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA

Shay, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA

Baker, LA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA

Henkemeyer, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA
[13]
Neuronal differentiation in the adult hippocampus recapitulates embryonic development
[J].
Espósito, MS
;
Piatti, VC
;
Laplagne, DA
;
Morgenstern, NA
;
Ferrari, CC
;
Pitossi, FJ
;
Schinder, AF
.
JOURNAL OF NEUROSCIENCE,
2005, 25 (44)
:10074-10086

Espósito, MS
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina

Piatti, VC
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina

论文数: 引用数:
h-index:
机构:

Morgenstern, NA
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina

Ferrari, CC
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina

Pitossi, FJ
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina

Schinder, AF
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina
[14]
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis
[J].
Gale, NW
;
Holland, SJ
;
Valenzuela, DM
;
Flenniken, A
;
Pan, L
;
Ryan, TE
;
Henkemeyer, M
;
Strebhardt, K
;
Hirai, H
;
Wilkinson, DG
;
Pawson, T
;
Davis, S
;
Yancopoulos, GD
.
NEURON,
1996, 17 (01)
:9-19

Gale, NW
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Holland, SJ
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Valenzuela, DM
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Flenniken, A
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Pan, L
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Ryan, TE
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Henkemeyer, M
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Strebhardt, K
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Hirai, H
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Wilkinson, DG
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Pawson, T
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Davis, S
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591

Yancopoulos, GD
论文数: 0 引用数: 0
h-index: 0
机构: REGENERON PHARMACEUT INC,TARRYTOWN,NY 10591
[15]
GABA regulates synaptic integration of newly generated neurons in the adult brain
[J].
Ge, SY
;
Goh, ELK
;
Sailor, KA
;
Kitabatake, Y
;
Ming, GL
;
Song, HJ
.
NATURE,
2006, 439 (7076)
:589-593

Ge, SY
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Neurol, Inst Cell Engn, Baltimore, MD 21205 USA

Goh, ELK
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Neurol, Inst Cell Engn, Baltimore, MD 21205 USA

Sailor, KA
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Neurol, Inst Cell Engn, Baltimore, MD 21205 USA

Kitabatake, Y
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Neurol, Inst Cell Engn, Baltimore, MD 21205 USA

Ming, GL
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Neurol, Inst Cell Engn, Baltimore, MD 21205 USA

Song, HJ
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Inst Cell Engn, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Inst Cell Engn, Baltimore, MD 21205 USA
[16]
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
[J].
Gong, SC
;
Zheng, C
;
Doughty, ML
;
Losos, K
;
Didkovsky, N
;
Schambra, UB
;
Nowak, NJ
;
Joyner, A
;
Leblanc, G
;
Hatten, ME
;
Heintz, N
.
NATURE,
2003, 425 (6961)
:917-925

Gong, SC
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Zheng, C
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Doughty, ML
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Losos, K
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Didkovsky, N
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Schambra, UB
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Nowak, NJ
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Joyner, A
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Leblanc, G
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Hatten, ME
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

Heintz, N
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
[17]
Nuk controls pathfinding of commissural axons in the mammalian central nervous system
[J].
Henkemeyer, M
;
Orioli, D
;
Henderson, JT
;
Saxton, TM
;
Roder, J
;
Pawson, T
;
Klein, R
.
CELL,
1996, 86 (01)
:35-46

论文数: 引用数:
h-index:
机构:

Orioli, D
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA

Henderson, JT
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA

Saxton, TM
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA

Roder, J
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA

Pawson, T
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA

Klein, R
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA
[18]
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
[J].
Himanen, JP
;
Chumley, MJ
;
Lackmann, M
;
Li, C
;
Barton, WA
;
Jeffrey, PD
;
Vearing, C
;
Geleick, D
;
Feldheim, DA
;
Boyd, AW
;
Henkemeyer, M
;
Nikolov, DB
.
NATURE NEUROSCIENCE,
2004, 7 (05)
:501-509

Himanen, JP
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Chumley, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Lackmann, M
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Li, C
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Barton, WA
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Jeffrey, PD
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Vearing, C
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Geleick, D
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Feldheim, DA
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Boyd, AW
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Henkemeyer, M
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Nikolov, DB
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA
[19]
EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping
[J].
Hindges, R
;
McLaughlin, T
;
Genoud, N
;
Henkemeyer, M
;
O'Leary, DDM
.
NEURON,
2002, 35 (03)
:475-487

论文数: 引用数:
h-index:
机构:

McLaughlin, T
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA

Genoud, N
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA

Henkemeyer, M
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA

O'Leary, DDM
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA
[20]
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
[J].
Holland, SJ
;
Gale, NW
;
Mbamalu, G
;
Yancopoulos, GD
;
Henkemeyer, M
;
Pawson, T
.
NATURE,
1996, 383 (6602)
:722-725

Holland, SJ
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA

Gale, NW
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA

Mbamalu, G
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA

Yancopoulos, GD
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA

论文数: 引用数:
h-index:
机构:

Pawson, T
论文数: 0 引用数: 0
h-index: 0
机构: MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAMME MOL BIOL & CANC,TORONTO,ON M5G 1X5,CANADA