Studying vascular development in the zebrafish

被引:34
作者
Vogel, AM [1 ]
Weinstein, BM [1 ]
机构
[1] NICHD, Genet Mol Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/S1050-1738(01)00068-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The zebrafish, a genetically accessible vertebrate with an externally developing, optically clear embryo, is ideally suited for in vivo functional dissection of the embryonic development of the circulatory system. Here, we review the advantages of the zebrafish as a model system for studying vascular development, and describe genetic and experimental tools, methods and resources that have been developed to exploit these advantages. We also discuss briefly how some of these tools and methods can be brought to bear on problems of relevance to human health. (Trends Cardiovasc Med 2000;10:352-360). (C) 2001, Elsevier Science Inc.
引用
收藏
页码:352 / 360
页数:9
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