CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness

被引：143

作者：

Michl, P

Ramjaun, AR

Pardo, OE

Warne, PH

Wagner, M

Poulsom, R

D'Arrigo, C

Ryder, K

Menke, A

Gress, T

Downward, J

机构：

[1] Canc Res UK London Res Inst, Signal Transduct Lab, London WC2A 3PX, England

[2] Canc Res UK London Res Inst, Situ Hybridisat Serv, London WC2A 3PX, England

[3] Univ Ulm Klinikum, Innere Med Abt 1, D-89081 Ulm, Germany

[4] Guys Hosp, Canc Res UK Breast Canc Pathol Lab, London SE1 9RT, England

[5] Guys Hosp, Clin Oncol Unit, London SE1 9RT, England

来源：

CANCER CELL | 2005年 / 7卷 / 06期

关键词：

D O I：

10.1016/j.ccr.2005.05.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CUTL1, also known as CDP, Cut, or Cux-1, is a homeodomain transcriptional regulator known to be involved in development and cell cycle progression. Here we report that CUTL1 activity is associated with increased migration and invasiveness in numerous tumor cell lines, both in vitro and in vivo. Furthermore, we identify CUTL1 as a transcriptional target of transforming growth factor P and a mediator of its promigratory effects. CUTL1 activates a transcriptional program regulating genes involved in cell motility, invasion, and extracellular matrix composition. CUTL1 expression is significantly increased in high-grade carcinomas and is inversely correlated with survival in breast cancer. This suggests that CUTL1 plays a central role in coordinating a gene expression program associated with cell motility and tumor progression.

引用

页码：521 / 532

页数：12

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[1] A large-scale RNAi screen in human cells identifies new components of the p53 pathway [J].