Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues

被引：100

作者：

Anraku, Yasutaka ^{[1
]}

Kishimura, Akihiro ^{[1
]}

Kobayashi, Atsushi ^{[1
]}

Oba, Makoto ^{[2
]}

Kataoka, Kazunori ^{[1
,2
,3
,4
]}

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Clin Vasc Regenerat, Bunkyo Ku, Tokyo 1130033, Japan

[3] Univ Tokyo, Ctr NanoBio Integrat, Bunkyo Ku, Tokyo 1138656, Japan

[4] Japan Sci & Technol Agcy, CREST, Chiyoda Ku, Tokyo 1020075, Japan

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 21期

基金：

日本科学技术振兴机构;

关键词：

POLYION COMPLEX VESICLES; DRUG-DELIVERY; NANOPARTICLES; EXTRAVASATION; NANOCARRIERS; DESIGN; PAIR;

D O I：

10.1039/c1cc11465d

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Selective disposition of nanocarriers into target tissue is an essential issue in drug delivery. Critical size of nanocarriers (similar to 150 nm) discriminating the permeability into normal and tumor tissues was determined by the use of size-tunable, polyion complex hollow vesicles (PICsome) as a ruler.

引用

收藏

页码：6054 / 6056

页数：3

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