pH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

被引：55

作者：

Kishimura, Akihiro ^{[1
]}

Liamsuwan, Sittipong ^{[2
]}

Matsuda, Hiroyuki ^{[2
]}

Dong, Wen-Fei ^{[1
]}

Osada, Kensuke ^{[1
]}

Yamasaki, Yuichi ^{[1
]}

Kataoka, Kazunori ^{[1
,2
,3
,4
]}

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan

[2] Univ Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan

[3] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Div Clin Biotechnol,Bunkyo Ku, Tokyo 1130033, Japan

[4] Univ Tokyo, Ctr NanoBio Integrat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

SOFT MATTER | 2009年 / 5卷 / 03期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

CHARGED BLOCK-COPOLYMERS; NONVIRAL GENE VECTORS; DRUG-DELIVERY; MICELLES; RELEASE; POLYMER; PAIR; ENCAPSULATION; ASSEMBLIES; POLYPLEX;

D O I：

10.1039/b815884c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.

引用

页码：529 / 532

页数：4

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