Biofunctionalized lipid-polymer hybrid nanocontainers with controlled permeability

被引：15

作者：

Dudia, Alma ^{[1
]}

Kocer, Armagan ^{[2
]}

Subramaniam, Vinod ^{[1
]}

Kanger, Johannes S. ^{[1
]}

机构：

[1] Univ Twente, BMTI Inst Biomed Technol, NL-7500 AE Enschede, Netherlands

[2] BioMaDe Technol Fdn, NL-9747 AG Groningen, Netherlands

来源：

NANO LETTERS | 2008年 / 8卷 / 04期

关键词：

D O I：

10.1021/nl073211b

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

We have successfully developed, for the first time, a novel polymer-lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.

引用

页码：1105 / 1110

页数：6

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