pH-induced release from P2VP-PEO block copolymer vesicles

被引：140

作者：

Borchert, Uwe

Lipprandt, Ute

Bilang, Matthias

Kimpfler, Andrea

Rank, Anja

Peschka-Suess, Regine

Schubert, Rolf

Lindner, Peter

Forster, Stephan ^{[1
]}

机构：

[1] Univ Hamburg, Inst Phys Chem, D-20146 Hamburg, Germany

[2] Univ Freiburg, Inst Pharmaceut, D-79104 Freiburg, Germany

[3] Inst Max Von Laue Paul Langevin, F-38042 Grenoble 9, France

来源：

LANGMUIR | 2006年 / 22卷 / 13期

关键词：

D O I：

10.1021/la060227t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pH-induced release of hydrophilic dyes from poly(2-vinylpyridine-b-ethylene oxide) (P2VP-PEO) block copolymer vesicles is investigated. The structure of the vesicles is characterized using small-angle neutron scattering (SANS) and cryo-electron microscopy (cryo-TEM). A decrease of the pH below 5 leads to protonation and dissolution of the poly-2-vinylpyridine blocks which induces rupture and dissolution of the vesicle membrane. Details of the rupture, dissolution, and release process are studied by fluorescence video microscopy, gel electrophoresis, and high-performance ultrafiltration.

引用

页码：5843 / 5847

页数：5

共 31 条

[1] Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles [J].