The secret life of ACE2 as a receptor for the SARS virus

被引：113

作者：

Dimitrov, DS ^{[1
]}

机构：

[1] NIH, NCI Frederick, CCR, LECB,Human Immunovirol & Computat Biol Grp, Ft Detrick, MD 21702 USA

来源：

CELL | 2003年 / 115卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(03)00976-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.

引用

页码：652 / 653

页数：2

共 8 条

[1] The coronavirus spike protein is a class I virus fusion protein: Structural and functional characterization of the fusion core complex [J].

Bosch, BJ ;

van der Zee, R ;

de Haan, CAM ;

Rottier, PJM .

JOURNAL OF VIROLOGY, 2003, 77 (16) :8801-8811

[2] Human coronavirus 229E:: Receptor binding domain and neutralization by soluble receptor at 37°C [J].

Breslin, JJ ;

Mork, I ;

Smith, MK ;

Vogel, LK ;

Hemmila, EM ;

Bonavia, A ;

Talbot, PJ ;

Sjöström, H ;

Norén, O ;

Holmes, KV .

JOURNAL OF VIROLOGY, 2003, 77 (07) :4435-4438

[3] A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 [J].

Donoghue, M ;

Hsieh, F ;

Baronas, E ;

Godbout, K ;

Gosselin, M ;

Stagliano, N ;

Donovan, M ;

Woolf, B ;

Robison, K ;

Jeyaseelan, R ;

Breitbart, RE ;

Acton, S .

CIRCULATION RESEARCH, 2000, 87 (05) :E1-E9

[4] Coronavirus spike proteins in viral entry and pathogenesis [J].

Gallagher, TM ;

Buchmeier, MJ .

VIROLOGY, 2001, 279 (02) :371-374

[5] Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus [J].

Li, WH ;

Moore, MJ ;

Vasilieva, N ;

Sui, JH ;

Wong, SK ;

Berne, MA ;

Somasundaran, M ;

Sullivan, JL ;

Luzuriaga, K ;

Greenough, TC ;

Choe, H ;

Farzan, M .

NATURE, 2003, 426 (6965) :450-454

[6] Characterization of a novel coronavirus associated with severe acute respiratory syndrome [J].

Rota, PA ;

Oberste, MS ;

Monroe, SS ;

Nix, WA ;

Campagnoli, R ;

Icenogle, JP ;

Peñaranda, S ;

Bankamp, B ;

Maher, K ;

Chen, MH ;

Tong, SX ;

Tamin, A ;

Lowe, L ;

Frace, M ;

DeRisi, JL ;

Chen, Q ;

Wang, D ;

Erdman, DD ;

Peret, TCT ;

Burns, C ;

Ksiazek, TG ;

Rollin, PE ;

Sanchez, A ;

Liffick, S ;

Holloway, B ;

Limor, J ;

McCaustland, K ;

Olsen-Rasmussen, M ;

Fouchier, R ;

Günther, S ;

Osterhaus, ADME ;

Drosten, C ;

Pallansch, MA ;

Anderson, LJ ;

Bellini, WJ .

SCIENCE, 2003, 300 (5624) :1394-1399

[7] The SARS-CoV S glycoprotein: expression and functional characterization [J].

Xiao, XD ;

Chakraborti, S ;

Dimitrov, AS ;

Gramatikoff, K ;

Dimitrov, DS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 312 (04) :1159-1164

[8] HUMAN AMINOPEPTIDASE-N IS A RECEPTOR FOR HUMAN CORONAVIRUS-229E [J].

YEAGER, CL ;

ASHMUN, RA ;

WILLIAMS, RK ;

CARDELLICHIO, CB ;

SHAPIRO, LH ;

LOOK, AT ;

HOLMES, KV .

NATURE, 1992, 357 (6377) :420-422

← 1 →