Antifatigue effects of coenzyme Q10 during physical fatigue

被引：124

作者：

Mizuno, Kei ^{[1
,2
]}

Tanaka, Masaaki ^{[1
,2
]}

Nozaki, Satoshi ^{[1
,2
]}

Mizuma, Hiroshi ^{[1
,2
]}

Ataka, Suzuka ^{[1
,2
]}

Tahara, Tsuyoshi ^{[1
,2
]}

Sugino, Tomohiro ^{[3
]}

Shirai, Tomoko ^{[3
]}

Kajimoto, Yoshitaka ^{[3
]}

Kuratsune, Hirohiko ^{[2
,4
]}

Kajimoto, Osami ^{[3
,5
]}

Watanabe, Yasuyoshi ^{[1
,2
]}

机构：

[1] Osaka City Univ, Grad Sch, Dept Physiol, Osaka 558, Japan

[2] Japenese Govt, Minst Educ Culture Sports Sci & Technol, Century COE Program Base Overcome Fatigue 21, Osaka, Japan

[3] Soiken Incorp, Osaka, Japan

[4] Kansai Univ Welfare Sci, Fac Hlth Sci Welfare, Dept Hlth Sci, Osaka, Japan

[5] Osaka Univ Foreign Study, Ctr Hlth Care, Osaka, Japan

来源：

NUTRITION | 2008年 / 24卷 / 04期

关键词：

fatigue; exercise; coenzyme Q10; antifatigue; physical performance; bicycle ergometer;

D O I：

10.1016/j.nut.2007.12.007

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objective: This study examined the effects of coenzyme Q 10 administration on physical fatigue. Methods: In a double-blinded, placebo-controlled, three crossover design, 17 healthy volunteers were randomized,to oral coenzyme Q10 (100 or 300 mg/d) or placebo administration for 8 d. As a fatigue-inducing physical task, subjects performed workload trials on a bicycle ergometer at fixed workloads twice for 2 h and then rested for 4 h. During the physical tasks, subjects performed non-workload trials with maximum velocity for 10 s at 30 min (30-min trial) after the start of physical tasks and 30 min before the end of the tasks (210-min trial). Results: The change in maximum velocity from the 30- to the 210-min trial in the 300-mg coenzyme Q10-administered group was higher than that in the placebo group. In addition, subjective fatigue sensation measured on a visual analog scale in the 300-mg coenzyme Q10-administered group after the fatigue-inducing physical task and recovery period was alleviated when compared with that in the placebo group. Conclusion: Oral administration of coenzyme Q10 improved subjective fatigue sensation and physical performance during fatigue-inducing workload trials and might prevent unfavorable conditions as a result of physical fatigue. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：293 / 299

页数：7