Highly efficient and versatile chemoselective addition of amines to epoxides in water catalyzed by erbium(III) triflate

被引：66

作者：

Procopio, Antonio ^{[1
]}

Gaspari, Marco ^{[1
]}

Nardi, Monica ^{[2
]}

Oliverio, Manuela ^{[1
]}

Rosati, Ornelio ^{[3
]}

机构：

[1] Univ Magna Grascia Complesso Nini Barbieri, Dipartimento Farmaco Biol, I-88021 Roccelletta Di Borgia, CZ, Italy

[2] Univ Calabria, Dipartimento Chim, I-87030 Arcavacata Di Rende, CS, Italy

[3] Univ Perugia, Dipartimento Chim & Tecnol Farm, I-06123 Perugia, PG, Italy

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 14期

关键词：

Lewis acid catalysis; Erbium(III) triflate; epoxide; aminolysis; beta-aminoalcohol;

D O I：

10.1016/j.tetlet.2008.02.010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Er(OTf)(3) is proposed as a highly efficient and reusable catalyst for the opening of epoxides in water with aliphatic as well as aromatic amines leading to the synthesis of beta-amino alcohols. The aqueous conditions employed in the present method will make it 'environmentally friendly' and potentially useful for industrial applications. (C) 2008 Elsevier Ltd. All rights reserved.

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页码：2289 / 2293

页数：5

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