Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

被引：692

作者：

Sanacora, Gerard ^{[2
]}

Zarate, Carlos A. ^{[1
]}

Krystal, John H. ^{[2
]}

Manji, Husseini K. ^{[1
]}

机构：

[1] NIMH, Mol Pathophysiol Lab, Mood & Anxiety Disorders Res Program, NIH, Bethesda, MD 20892 USA

[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 05期

关键词：

D O I：

10.1038/nrd2462

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of millions of individuals worldwide. To date, the monoaminergic systems (serotonergic, noradrenergic and dopaminergic) in the brain have received the greatest attention in neurobiological studies of mood disorders, and most therapeutics target these systems. However, there is growing evidence that the glutamatergic system is central to the neurobiology and treatment of these disorders. Here, we review data supporting the involvement of the glutamatergic system in mood-disorder pathophysiology as well as the efficacy of glutamatergic agents in mood disorders. We also discuss exciting new prospects for the development of improved therapeutics for these devastating disorders.

引用

页码：426 / 437

页数：12

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