Structures of immunophilins and their ligand complexes

被引：96

作者：

Dornan, J

Taylor, P

Walkinshaw, MD

机构：

[1] Univ Edinburgh, Edinburgh EH9 3JR, Midlothian, Scotland

[2] Cyclacel Ltd, Dundee DD1 5JJ, Scotland

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 12期

关键词：

comparison of X-ray and NMR structures of cyclophilins and FKBPs; variation among species; families of cyclophilin ligands and their structures; families of FKBP ligands and their structures; immunophilin - protein complexes;

D O I：

10.2174/1568026033451899

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This review includes an analysis of available X-ray and NMR structures of both members of the immunophilin family; cyclophilins and the FK-506 binding proteins (FKBPs). Available structures are compared and contrasted to highlight different structural features seen both within and between species. Each immunophilin family has been structurally characterised with a variety of small molecule ligands, principally immunosuppressive drugs and their analogues and an overview of these complexes is also presented. Currently the Protein Data Base contains over 60 entries for cyclophilins and over 40 entries for FKBPs. A number of FKBP related structures are also available including structures of MIP (Macrophage Infectivity Potentiator protein) from Legionella pneumophila and Trypanosoma cruzi and Trigger Factor from Mycoplasma genitalium. For all structures discussed in the review a summary of the available biological data is also presented.

引用

收藏

页码：1392 / 1409

页数：18

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