Alzheimer's disease and melatonin

被引：12

作者：

Matsubara, E ^{[1
]}

Shoji, M ^{[1
]}

Murakami, T ^{[1
]}

Kawarabayashi, T ^{[1
]}

Abe, K ^{[1
]}

机构：

[1] Okayama Univ, Dept Neurol, Grad Sch Med & Dent, Okayama 7008558, Japan

来源：

MOLECULAR MECHANISMS AND EPOCHAL THERAPEUTICS OF ISCHEMIC STROKE AND DEMENTIA | 2003年 / 1252卷

关键词：

melatonin; amyloid beta; Alzheimer's disease; anti-amyloidogenic properties of melatonin; antioxidant properties of melatonin;

D O I：

10.1016/S0531-5131(03)00019-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Melatonin has a two different mechanism of action to prevent pro-amyloidogenic environment that leads to Alzheimer's amyloid beta (Abeta) amyloidosis: (1) anti-amyloidogenic and (2) anti-oxidant properties. The former causes the reduction of the beta-sheet-rich conformer which becomes aggregated and neurotoxic, contributing to neuroprotection. The latter also results in the reduction of neuronal damage mediated by Abeta-mediated oxidative stress. These strong neuroprotective effects may bear relevance to pathogenesis and therapy of Alzheimer's disease (AD). This review focuses on melatonin as a therapeutic agent for Alzheimer's disease. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：395 / 398

页数：4

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