Mechanisms of disease:: adipocytokines and visceral adipose tissue-emerging role in intestinal and mesenteric diseases

被引：108

作者：

Schäffler, A ^{[1
]}

Schölmerich, J ^{[1
]}

Büchler, C ^{[1
]}

机构：

[1] Univ Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany

来源：

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY | 2005年 / 2卷 / 02期

关键词：

adipocytolkines; creeping fat; Crohn's disease; mesenteric panniculitis; visceral adipose tissue;

D O I：

10.1038/ncpgasthep0090

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Adipose tissue has long been regarded as a passive type of connective tissue that stores energy as triglycerides and releases energy as free fatty acids, however, this point of view has now changed. The wide variety of products expressed and secreted by adipose tissue, such as adiponectin, leptin, and resistin, mean that the total adipose tissue mass can be defined as a real endocrine organ. The anatomic, metabolic and biochemical characteristics of visceral adipose tissue make it interesting in the context of intestinal and mesenteric diseases. These characteristics include increased lipolysis, venous drainage via the portal vein and local glucocorticoid excess owing to the specific expression of 11-β-hydroxysteroid-dehydrogenase type 1. In this review, the role of the visceral adipose tissue and its secretory products in intestinal and mesenteric diseases is systematically reviewed, with special focus on 'creeping fat' in Crohn's disease and mesenteric panniculitis.

引用

页码：103 / 111

页数：9

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