Cytotoxic T-cell abundance and virus load in human immunodeficiency virus type 1 and human T-cell leukaemia virus type 1

被引:48
作者
Wodarz, D
Hall, SE
Usuku, K
Osame, M
Ogg, GS
McMichael, AJ
Nowak, MA
Bangham, CRM
机构
[1] St Marys Hosp, Dept Immunol, Imperial Coll Sch Med, London W2 1PG, England
[2] Inst Adv Study, Princeton, NJ 08540 USA
[3] Kagoshima Univ, Fac Med, Dept Med Informat, Kagoshima 8908520, Japan
[4] Kagoshima Univ, Fac Med, Dept Internal Med 3, Kagoshima 8908520, Japan
[5] John Radcliffe Hosp, Mol Immunol Grp, Nuffield Dept Med, Oxford OX3 9DU, England
关键词
human immunodeficiency virus type 1; human T-cell leukaemia virus type 1; virus load; cytotoxic T lymphocyte; correlation; mathematical models;
D O I
10.1098/rspb.2001.1608
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The correlation between virus load and specific cytotoxic T-lymphocyte (CTL) frequency during the chronic phase in human immunodeficiency virus type 1 (HIV-1) infection has been found to be negative in cross-sectional studies. We report here that, in infection with the related retrovirus human T-cell leukaemia virus type 1 (HTLV-1), the correlation is positive in asymptomatic carriers and zero in patients with the associated inflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We demonstrate that the direction of the correlation may depend on the efficacy of the CTL response using mathematical models. We conclude that the CTL response is effective in asymptomatic carriers of HTLV-1, but ineffective in patients with HAM/TSP. Virus-mediated impairment of specific CTL production in HIV-1 infection can account for the negative correlation observed.
引用
收藏
页码:1215 / 1221
页数:7
相关论文
共 38 条
[1]  
ANDERSON R M, 1991
[2]   POPULATION BIOLOGY OF INFECTIOUS-DISEASES .1. [J].
ANDERSON, RM ;
MAY, RM .
NATURE, 1979, 280 (5721) :361-367
[3]  
[Anonymous], 1981, Theoretical Ecology: Principles and Applications
[4]   HIV-2-SPECIFIC CYTOTOXIC T-LYMPHOCYTE ACTIVITY IS INVERSELY RELATED TO PROVIRAL LOAD [J].
ARIYOSHI, K ;
CHAM, F ;
BERRY, N ;
JAFFAR, S ;
SABALLY, S ;
CORRAH, T ;
WHITTLE, H .
AIDS, 1995, 9 (06) :555-559
[5]   NATURALLY-OCCURRING HIV-1 ISOLATES WITH DIFFERENCES IN REPLICATIVE CAPACITY ARE DISTINGUISHED BY INSITU HYBRIDIZATION OF INFECTED-CELLS [J].
ASJO, B ;
SHARMA, UK ;
MORFELDTMANSON, L ;
MAGNUSSON, A ;
BARKHEM, T ;
ALBERT, J ;
OLAUSSON, E ;
VONGEGERFELT, A ;
LIND, B ;
BIBERFELD, P ;
FENYO, EM .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (10) :1177-1182
[6]  
Bangham C R, 1993, Curr Opin Neurobiol, V3, P773, DOI 10.1016/0959-4388(93)90152-O
[7]   Genetic control and dynamics of the cellular immune response to the human T-cell leukaemia virus, HTLV-I [J].
Bangham, CRM ;
Hall, SE ;
Jeffery, KJM ;
Vine, AM ;
Witkover, A ;
Nowak, MA ;
Wodarz, D ;
Usuku, K ;
Osame, M .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1999, 354 (1384) :691-700
[8]   INCREASED VIRAL BURDEN AND CYTOPATHICITY CORRELATE TEMPORALLY WITH CD4+ T-LYMPHOCYTE DECLINE AND CLINICAL PROGRESSION IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED INDIVIDUALS [J].
CONNOR, RI ;
MOHRI, H ;
CAO, YZ ;
HO, DD .
JOURNAL OF VIROLOGY, 1993, 67 (04) :1772-1777
[9]   Target cell limited and immune control models of HIV infection: A comparison [J].
De Boer, RJ ;
Perelson, AS .
JOURNAL OF THEORETICAL BIOLOGY, 1998, 190 (03) :201-214
[10]   Broader tropism and higher cytopathicity for CD4(+) T cells of a syncytium-inducing compared to a non-syncytium-inducing HIV-1 isolate as a mechanism for accelerated CD4(+) T cell decline in vivo [J].
Fouchier, RAM ;
Meyaard, L ;
Brouwer, M ;
Hovenkamp, E ;
Schuitemaker, H .
VIROLOGY, 1996, 219 (01) :87-95