A generalized Luria-Delbruck model

被引:52
作者
Dewanji, A
Luebeck, EG
Moolgavkar, SH
机构
[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
[2] Indian Stat Inst, Div Appl Sci, Kolkata 700108, W Bengal, India
关键词
Luria-Delbruck distribution; fluctuation analysis; Gompertz growth; birth-death process; carcinogenesis; mutant clones;
D O I
10.1016/j.mbs.2005.07.003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We develop extensions of the Luria-Delbruck model that explicitly consider non-exponential growth of normal cells and a birth-death process with mean exponential or Gompertz growth of mutants. Death of mutant cells can be important in clones arising during cancer progression. The use of a birth-death process for growth of mutant cells, as opposed to a pure birth process as in previous work on the Luria-Delbruck model, leads to a large increase in the extra Poisson variation in the size of the mutant cell populations, which needs to be addressed in statistical analyses. We also discuss connections with previous work on carcinogenesis models. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:140 / 152
页数:13
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