An efficient access to (R)- and (S)-6,6'-dimethoxy-2,2'-diiodo-1,1'-biphenyl

被引：14

作者：

Cereghetti, M

Schmid, R

Schonholzer, P

Rageot, A

机构：

[1] F.Hoffmann-La Roche Ltd., Pharmaceuticals Division, Preclinical Research

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 30期

关键词：

D O I：

10.1016/0040-4039(96)01089-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a better procedure than the known for (rac)-2a, the diamine (rac)-2b was resolved for the first time with the new resolving agent (R,R)- and (S,S)-2,3-di(phenylaminocarbonyl)tartaric acid (5c) (40-45% weight yields; >99% ee). The diamines (R)- or (S)-2a and 2b were converted with >98% stereochemical retention into the diiodides (R)- and (S)-3a and 3b and subsequently, without loss of optical purify, diphenylphosphinated to the known diphosphines (R)- and (S)-4a and 4b. Copyright (C) 1996 Elsevier Science Ltd

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页码：5343 / 5346

页数：4

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