Efficient complexation of N-acetyl amino acid carboxylates in water by an artificial receptor:: Unexpected cooperativity in the binding of glutamate but not aspartate

被引：53

作者：

Schmuck, C ^{[1
]}

Geiger, L ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 30期

关键词：

D O I：

10.1021/ja052699k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new tris-cation 1 binds N-acetyl amino acid carboxylates in water even at millimolar salt concentrations with Kass ≈ 103 M-1 due to a clustering of electrostatic interactions. Binding is efficient enough to allow a naked-eyed detection using an indicator displacement assay. Furthermore, receptor 1 shows an unexpected 2:1 complex formation with strong positive cooperativity with glutamate but not aspartate. Copyright © 2005 American Chemical Society.

引用

页码：10486 / 10487

页数：2

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