A model for neuronal competition during development

被引：119

作者：

Deppmann, Christopher D. ^{[1
,2
]}

Mihalas, Stefan ^{[1
,3
]}

Sharma, Nikhil ^{[1
,2
]}

Lonze, Bonnie E. ^{[1
,2
]}

Niebur, Ernst ^{[1
,3
]}

Ginty, David D. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Solomon Snyder Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Zanvyl Krieger Mind Brain Inst, Baltimore, MD 21205 USA

来源：

SCIENCE | 2008年 / 320卷 / 5874期

关键词：

D O I：

10.1126/science.1152677

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target- derived nerve growth factor ( NGF) promoted expression of its own receptor TrkA in mouse and rat neurons and prolonged TrkA- mediated signals. NGF also controlled expression of brain- derived neurotrophic factor and neurotrophin- 4, which, through the receptor p75, can kill neighboring neurons with low retrograde NGF- TrkA signaling whereas neurons with high NGF- TrkA signaling are protected. Perturbation of any of these feedback loops disrupts the dynamics of competition. We suggest that three target- initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects.

引用

页码：369 / 373

页数：5

共 21 条

[1] The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death [J].

Bamji, SX ;

Majdan, M ;

Pozniak, CD ;

Belliveau, DJ ;

Aloyz, R ;

Kohn, J ;

Causing, CG ;

Miller, FD .

JOURNAL OF CELL BIOLOGY, 1998, 140 (04) :911-923

[2] The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo [J].

Brennan, C ;

Rivas-Plata, K ;

Landis, SC .

NATURE NEUROSCIENCE, 1999, 2 (08) :699-705

[3]

Campenot R B, 1979, Methods Enzymol, V58, P302

[4] MICE LACKING NERVE GROWTH-FACTOR DISPLAY PERINATAL LOSS OF SENSORY AND SYMPATHETIC NEURONS YET DEVELOP BASAL FOREBRAIN CHOLINERGIC NEURONS [J].

CROWLEY, C ;

SPENCER, SD ;

NISHIMURA, MC ;

CHEN, KS ;

PITTSMEEK, S ;

ARMANINI, MP ;

LING, LH ;

MCMAHON, SB ;

SHELTON, DL ;

LEVINSON, AD ;

PHILLIPS, HS .

CELL, 1994, 76 (06) :1001-1011

[5] NGF signaling in sensory neurons: Evidence that early endosomes carry NGF retrograde signals [J].

Delcroix, JD ;

Valletta, JS ;

Wu, CB ;

Hunt, SJ ;

Kowal, AS ;

Mobley, WC .

NEURON, 2003, 39 (01) :69-84

[6] Heterogeneous requirement of NGF for sympathetic target innervation in vivo [J].

Glebova, NO ;

Ginty, DD .

JOURNAL OF NEUROSCIENCE, 2004, 24 (03) :743-751

[7] PROLIFERATION, DIFFERENTIATION AND DEGENERATION IN THE SPINAL GANGLIA OF THE CHICK EMBRYO UNDER NORMAL AND EXPERIMENTAL CONDITIONS [J].

HAMBURGER, V ;

LEVIMONTALCINI, R .

JOURNAL OF EXPERIMENTAL ZOOLOGY, 1949, 111 (03) :457-501

[8] Dynein motors transport activated Trks to promote survival of target-dependent neurons [J].

Heerssen, HM ;

Pazyra, MF ;

Segal, RA .

NATURE NEUROSCIENCE, 2004, 7 (06) :596-604

[9] Long-distance retrograde neurotrophic signaling [J].

Howe, CL ;

Mobley, WC .

CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (01) :40-48

[10] A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling [J].

Kuruvilla, R ;

Zweifel, LS ;

Glebova, NO ;

Lonze, BE ;

Valdez, G ;

Ye, HH ;

Ginty, DD .

CELL, 2004, 118 (02) :243-255

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