Viscoelastic and biological performance of low-modulus, reactive calcium phosphate-filled, degradable, polymeric bone adhesives

被引：21

作者：

Abou Neel, Ensanya A. ^{[1
]}

Salih, Vehid ^{[1
]}

Revell, Peter A. ^{[1
]}

Young, Anne M. ^{[1
]}

机构：

[1] UCL, Eastman Dent Inst, London WC1X 8LD, England

来源：

ACTA BIOMATERIALIA | 2012年 / 8卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

Bone adhesive; Viscoelasticity; Creep; In vitro cell compatibility; MECHANICAL-PROPERTIES; CEMENT; ATTACHMENT; INTERFACE; COMPOSITE; STRENGTH; BEHAVIOR; PLATES;

D O I：

10.1016/j.actbio.2011.08.008

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The aim of this study was to investigate the effect of reactive mono- and tricalcium phosphate addition on the mechanical, surface free energy, degradation and cell compatibility properties of poly(lactide-co-propylene glycol-co-lactide) dimethacrylate (PPGLDMA) thin films. Dry composites containing up to 70 wt.% filler were in a flexible rubber state at body temperature. Filler addition increased the initial strength and Young's modulus and reduced the elastic and permanent deformation under load. The polymer had high polar surface free energy, which might enable greater spread upon bone. This was significantly reduced by filler addition but not by water immersion for 7 days. The samples exhibited reduced water sorption and associated bulk degradation when compared with previous work with thicker samples. Their cell compatibility was also improved. Filler raised water sorption and degradation but improved cell proliferation. The materials are promising bone adhesive candidates for low-load-bearing areas. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：313 / 320

页数：8

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