Searching for differentially expressed gene combinations

被引：40

作者：

Dettling, M ^{[1
]}

Gabrielson, E

Giovanni, P

机构：

[1] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA

[2] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

[3] Johns Hopkins Med Inst, Dept Biostat, Baltimore, MD 21205 USA

来源：

GENOME BIOLOGY | 2005年 / 6卷 / 10期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1186/gb-2005-6-10-r88

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We propose 'CorScor', a novel approach for identifying gene pairs with joint differential expression. This is defined as a situation with good phenotype discrimination in the bivariate, but not in the two marginal distributions. CorScor can be used to detect phenotype-related dependencies and interactions among genes. Our easily interpretable approach is scalable to current microarray dimensions and yields promising results on several cancer-gene-expression datasets.

引用

页数：10

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