The effect of feeding a diet naturally contaminated with deoxynivalenol (DON) and zearalenone (ZON) on the spleen and liver of sow and fetus from day 35 to 70 of gestation

被引：47

作者：

Tiemann, U. ^{[1
]}

Bruessow, K. -P. ^{[1
]}

Dannenberger, D. ^{[2
]}

Jonas, L. ^{[3
]}

Poehland, R. ^{[1
]}

Jaeger, K. ^{[4
]}

Daenicke, S. ^{[5
]}

Hagemann, E. ^{[6
]}

机构：

[1] FBN Res Inst Biol Farm Anim, Reprod Biol Unit, D-18196 Dummerstorf, Germany

[2] FBN Res Inst Biol Farm Anim, Unit Muscle Biol & Growth, D-18196 Dummerstorf, Germany

[3] Univ Rostock, Electron Microscop Ctr, D-18055 Rostock, Germany

[4] Univ Leipzig, Fac Vet Med, Inst Pathol, D-04103 Leipzig, Germany

[5] Fed Agr Res Ctr FAL, Inst Anim Nutr, D-38116 Braunschweig, Germany

[6] State Off Agr Food Safety & Fishery Mecklenberg W, Dept Contaminant & Residue Anal, D-18059 Rostock, Germany

来源：

TOXICOLOGY LETTERS | 2008年 / 179卷 / 03期

关键词：

Fusarium toxins; pregnant sows; fetus; liver; spleen;

D O I：

10.1016/j.toxlet.2008.04.016

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Pregnant sows were fed a control diet (CON, 0.15 mg deoxynivalenol (DON) and 0.0035 mg zearalenone (ZON) per kg diet) or diet containing 15% of Fusarium toxin contaminated triticale (MYCO, 4.42 mg DON and 0.048 mg ZON per kg diet) during days 35-70 of gestation. All sows were fed in a restricted feeding regimen with the same amount of feed (2000 g/d) over the whole study. At the end of the experiment, fetuses were delivered by Caesarian section and samples of spleen and liver of euthanized sows and fetuses were analyzed. At terminal necropsy, no macroscopic lesion was observed in any organ of either sows or fetuses. The histopathological data indicated significant alteration only in elevated iron staining in the red pulp of spleens in sows of MYCO group after 35 days of feeding. The presence of hemosiderin particles in the spleen sections was confirmed by transmission electron microscopical investigation and by an enhanced Fe 21 concentration in spleen. A glycogen increase (p < 0.05) was found in liver cells of fetuses in the experimental group. Together, the results provide evidence of spleen dysfunction (hemosiderosis) in sows fed a Fusarium toxin-contaminated wheat, however, with absence of clinical signs. Enhanced glycogen and an impairment of mitochondria in liver of fetuses was present when their mothers consumed the MYCO diet. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：113 / 117

页数：5

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