The therapeutic potential of mesenchymal stem cells

被引：122

作者：

Picinich, Sonia C.

Mishra, Pravin J.

Mishra, Prasun J.

Glod, John

Banerjee, Debabrata

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Pharmacol, New Brunswick, NJ 08903 USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Med, New Brunswick, NJ 08903 USA

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Pediat Oncol, New Brunswick, NJ 08903 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2007年 / 7卷 / 07期

关键词：

migration; regenerative medicine; stem cells; stromal cell-derived factor-1; tumor targeting;

D O I：

10.1517/14712598.7.7.965

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mesenchymal stem cells (MSCs) are multipotent cells with a number of potential therapeutic applications. At present, they are being used in a clinical trial for the treatment of myocardial infarction and are being studied as a therapy for other vascular disorders. Treatments of neurologic disorders and anticancer therapy with MSCs have progressed in light of the migratory properties of MSCs to brain injury and tumors. The osteogenic potential of MSCs is being exploited in work investigating their use in bone regeneration therapy, and the immunomodulatory function of MSCs is being evaluated as a possible therapy for graft-versus-host disease. Here, the authors review recent work contributing to the knowledge of MSC biology and the advances in gene therapy and tissue regeneration using MSCs.

引用

页码：965 / 973

页数：9

共 61 条

[31] Successful stem cell therapy using umbilical cord blood-derived multipotent stem cells for Buerger's disease and ischemic limb disease animal model [J].

Kim, Sung-Whan ;

Han, Hoon ;

Chae, Gue-Tae ;

Lee, Sung-Hoon ;

Bo, Sun ;

Yoon, Jung-Hee ;

Lee, Yong-Soon ;

Lee, Kwang-Soo ;

Park, Hwon-Kyum ;

Kang, Kyung-Sun .

STEM CELLS, 2006, 24 (06) :1620-1626

[32] Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses [J].

Komarova, S ;

Kawakami, Y ;

Stoff-Khalili, MA ;

Curiel, DT ;

Pereboeva, L .

MOLECULAR CANCER THERAPEUTICS, 2006, 5 (03) :755-766

[33] Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide [J].

Krampera, M ;

Glennie, S ;

Dyson, J ;

Scott, D ;

Laylor, R ;

Simpson, E ;

Dazzi, F .

BLOOD, 2003, 101 (09) :3722-3729

[34] Human mesenchymal stem cells (hMSCs) expressing truncated soluble vascular endothelial growth factor receptor (tsFlk-1) following lentiviral-mediated gene transfer inhibit growth of Burkitt's lymphoma in a murine model [J].

Kyriakou, Chara A. ;

Yong, Kwee L. ;

Benjamin, Reuben ;

Pizzey, Arnold ;

Dogan, Ahmet ;

Singh, Nalini ;

Davidoff, Andrew M. ;

Nathwani, Amit C. .

JOURNAL OF GENE MEDICINE, 2006, 8 (03) :253-264

[35] Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta [J].

Le Blanc, K ;

Götherström, C ;

Ringdén, O ;

Hassan, M ;

McMahon, R ;

Horwitz, E ;

Anneren, G ;

Axelsson, O ;

Nunn, J ;

Ewald, U ;

Nordén-Lindeberg, S ;

Jansson, M ;

Dalton, A ;

Åström, E ;

Westgren, M .

TRANSPLANTATION, 2005, 79 (11) :1607-1614

[36] HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells [J].

Le Blanc, K ;

Tammik, C ;

Rosendahl, K ;

Zetterberg, E ;

Ringdén, O .

EXPERIMENTAL HEMATOLOGY, 2003, 31 (10) :890-896

[37] Use of mesenchymal stem cells to facilitate bone regeneration in normal and chemotherapy-treated rats [J].

Lee, OK ;

Coathup, MJ ;

Goodship, AE ;

Blunn, GW .

TISSUE ENGINEERING, 2005, 11 (11-12) :1727-1735

[38] Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells [J].

Levy, YS ;

Merims, D ;

Panet, H ;

Barhum, Y ;

Melamed, E ;

Offen, D .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2003, 21 (02) :121-132

[39] Vascular endothelial growth factor-expressing mesenchymal stem cell transplantation for the treatment of acute myocardial infarction [J].

Matsumoto, R ;

Omura, T ;

Yoshiyama, M ;

Hayashi, T ;

Inamoto, S ;

Koh, KR ;

Ohta, K ;

Izumi, Y ;

Nakamura, Y ;

Akioka, K ;

Kitaura, Y ;

Takeuchi, K ;

Yoshikawa, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (06) :1168-1173

[40]

MENON LG, 2006, STEM CELLS

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