Formalin-induced pain is reduced in σ1 receptor knockout mice

被引：129

作者：

Cendán, CM

Pujalte, JM

Portillo-Salido, E

Montoliu, L

Baeyens, JM

机构：

[1] Univ Granada, Sch Med, Dept Pharmacol, Granada 18012, Spain

[2] Labs Dr Esteve SA, Target Validat Dept, Barcelona 08028, Spain

[3] CSIC, CNB, Dept Mol & Cellular Biol, E-28049 Madrid, Spain

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 511卷 / 01期

关键词：

sigma(1) receptor; formalin; non-acute pain;

D O I：

10.1016/j.ejphar.2005.01.036

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The role of sigma(1) receptors in non-acute pain has not been explored. In this study we show that both phases of formalin-induced pain were reduced by approximately 55% in sigma(1) receptor knockout mice in comparison to wild-type animals. These results suggest that the tonic pain induced by formalin is altered in mice lacking receptors, and highlight the potential usefulness of further studies of the role of sigma(1) receptors in models of non-acute pain. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：73 / 74

页数：2

共 7 条

[1]

Chaplan SR, 1997, J PHARMACOL EXP THER, V280, P829

[2]

CODERRE TJ, 1992, J NEUROSCI, V12, P3665

[3]

Modulation of NMDA and dopaminergic neurotransmissions by sigma ligands: Possible implications for the treatment of psychiatric disorders [J].