Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia

被引：312

作者：

Lino, M

Goto, K

Kakegawa, W

Okado, H

Sudo, M

Ishiuchi, S

Miwa, A

Takayasu, Y

Saito, I

Tsuzuki, K

Ozawa, S ^{[1
]}

机构：

[1] Gunma Univ, Sch Med, Gunma 3718511, Japan

[2] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan

[3] Univ Tokyo, Inst Med Sci, Tokyo 1080071, Japan

[4] Tokyo Metropolitan Inst Neurosci, Inst Neurosci, Dept Neurobiol, Fuchu, Tokyo 1838526, Japan

来源：

SCIENCE | 2001年 / 292卷 / 5518期

关键词：

D O I：

10.1126/science.1058827

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Glial cells express a variety of neurotransmitter receptors, Notably, Bergmann glial cells in the cerebellum have Ca2+-permeable alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) assembled without the GluR2 subunit, To elucidate the role of these Ca2+-permeable AMPARs, we converted them into Ca2+-impermeable receptors by adenoviral-mediated delivery of the GluR2 gene. This conversion retracted the glial processes ensheathing synapses on Purkinje cell dendritic spines and retarded the removal of synaptically released glutamate, Furthermore, it caused multiple innervation of Purkinje cells by the climbing fibers. Thus, the glial Ca2+-permeable AMPARs are indispensable for proper structural and functional relations between Bergmann glia and glutamatergic synapses.

引用

页码：926 / 929

页数：4

共 20 条

[1] Fast removal of synaptic glutamate by postsynaptic transporters [J].