The 20 years of PROSITE

被引：362

作者：

Hulo, Nicolas ^{[1
]}

Bairoch, Amos ^{[1
,2
]}

Bulliard, Virginie ^{[1
]}

Cerutti, Lorenzo ^{[3
]}

Cuche, Beatrice A. ^{[1
]}

de Castro, Edouard ^{[1
]}

Lachaize, Corinne ^{[1
]}

Langendijk-Genevaux, Petra S. ^{[1
]}

Sigrist, Christian J. A. ^{[1
]}

机构：

[1] Univ Geneva, Ctr Med Univ, SIB, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Struct Biol & Bioinformat Dept, CH-1211 Geneva, Switzerland

[3] UNIL Sorge, SIB, CH-1015 Lausanne, Switzerland

来源：

NUCLEIC ACIDS RESEARCH | 2008年 / 36卷

关键词：

D O I：

10.1093/nar/gkm977

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PROSITE consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them. It is complemented by ProRule, a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids. In this article, we describe the implementation of a new method to assign a status to pattern matches, the new PROSITE web page and a new approach to improve the specificity and sensitivity of PROSITE methods. The latest version of PROSITE (release 20.19 of 11 September 2007) contains 1319 patterns, 745 profiles and 764 ProRules. Over the past 2 years, about 200 domains have been added, and now 53 of UniProtKB/Swiss-Prot entries (release 54.2 of 11 September 2007) have a PROSITE match. PROSITE is available on the web at: http://www.expasy.org/prosite/.

引用

页码：D245 / D249

页数：5

共 14 条

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