Synthesis of (±)-5′-methoxyhydnocarpin-D, an inhibitor of the Staphylococcus aureus multidrug resistance pump

被引：8

作者：

Chan, KF

Zhao, YZ

Chow, LMC

Chan, TH ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chiral Technol, Kowloon, Hong Kong, Peoples R China

[3] State Key Lab Chinese Med & Mol Pharmacol, Schenzhen, Peoples R China

来源：

TETRAHEDRON | 2005年 / 61卷 / 16期

关键词：

Staphylococcus aureus; multidrug resistance; NorA; 5 '-methoxyhydnocarpin-D; Mitsunobu reaction;

D O I：

10.1016/j.tet.2005.02.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of regioisomerically pure (+/-)-5'-methoxyhydnocarpin-D (6) from commercially available vanillin (7), methyl gallate (9) and 2',4',6'-trihydroxyaceophenone (10) is achieved. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4149 / 4156

页数：8

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