Antituberculosis drugs: Drug interactions, adverse effects, and use in special situations. Part 2: Second line drugs

被引：76

作者：

Arbex, Marcos Abdo ^{[1
,2
]}

Lima Varella, Marilia de Castro ^{[3
]}

de Siqueira, Helio Ribeiro ^{[4
,5
]}

Finza de Mello, Fernando Augusto ^{[6
,7
]}

机构：

[1] Hosp Nestor Goulart Reis, Secretaria Estado Saude Estado Sao Paulo, Amer Brasiliense, SP, Brazil

[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Disciplina Clin Med, Sao Paulo, Brazil

[3] Univ Mogi das Cruzes, Fac Med, Disciplina Clin Med, Mogi Das Cruzes, SP, Brazil

[4] Univ Estado Rio de Janeiro, Fac Ciencias Med, Disciplina Pneumol & Tisiol, BR-20550011 Rio De Janeiro, Brazil

[5] Univ Estado Rio de Janeiro, Hosp Univ Pedro Ernesto, BR-20550011 Rio De Janeiro, Brazil

[6] Secretaria Estado Saude Estado Sao Paulo, Sao Paulo, Brazil

[7] Inst Clemente Ferreira, Sao Paulo, Brazil

来源：

JORNAL BRASILEIRO DE PNEUMOLOGIA | 2010年 / 36卷 / 05期

关键词：

Tuberculosis; Drug interactions; Antibiotics; antitubercular; Pharmacologic actions; Drug toxicity; multidrug-resistant; MULTIDRUG-RESISTANT TUBERCULOSIS; MYCOBACTERIUM-TUBERCULOSIS; FLUOROQUINOLONES; NEPHROTOXICITY; PHARMACOKINETICS; ETHIONAMIDE; PREGNANCY; OFLOXACIN; AGENTS;

D O I：

10.1590/S1806-37132010000500017

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

The main objectives of tuberculosis therapy are to cure the patients and to minimize the possibility of transmission of the bacillus to healthy subjects. Adverse effects of antituberculosis drugs or drug interactions (among antituberculosis drugs or between antituberculosis drugs and other drugs) can make it necessary to modify or discontinue treatment. We describe the general mechanism of action, absorption, metabolization, and excretion of the drugs used to treat multidrug resistant tuberculosis (aminoglycosides, fluoroquinolones, cycloserine/terizidone, ethionamide, capreomycin, and para-aminosalicylic acid). We describe adverse drug reactions and interactions (with other drugs, food, and antacids), as well as the most appropriate approach to special situations, such as pregnancy, breastfeeding, liver failure, and kidney failure.

引用

页码：641 / 656

页数：16

共 60 条

[1]

American Academy of Pediatrics Committee on Drugs, 2001, Pediatrics, V108, P776

[2]

[Anonymous], 2003, AM J RESP CRIT CARE, V167, P603

[3]

[Anonymous], 2008, Tuberculosis (Edinb), V88, P100, DOI 10.1016/S1472-9792(08)70007-6

[4]

[Anonymous], 2008, Tuberculosis (Edinb), V88, P127, DOI 10.1016/S1472-9792(08)70016-7

[5]

[Anonymous], 2008, Tuberculosis (Edinb), V88, P119, DOI 10.1016/S1472-9792(08)70013-1

[6]

[Anonymous], 2008, Tuberculosis (Edinb), V88, P106, DOI 10.1016/S1472-9792(08)70009-X

[7]

[Anonymous], 2009, Treatment of tuberculosis guidelines

[8]

[Anonymous], [No title captured]

[9]

The Newer Fluoroquinolones [J].

Bolan, Maureen K. .

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2009, 23 (04) :1027-+

[10]

*BRAS MIN SAUD FUN, 2002, CONTR TUB PROP INT E

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