Total synthesis of uvaricin

被引：56

作者：

Yazbak, A

Sinha, SC

Keinan, E

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Technion Israel Inst Technol, Dept Chem, IL-32000 Haifa, Israel

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 17期

关键词：

D O I：

10.1021/jo980453a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of naturally occurring (+)-uvaricin was achieved using three consecutive Sharpless asymmetric dihydroxylation (AD) reactions to place the necessary oxygen functions on a "naked" carbon skeleton in a regio- and enantioselectively controlled manner. The appropriate bis-THF ring system was constructed using a Williamson type etherification reaction on a functionalized bis-mesylate intermediate.

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收藏

页码：5863 / 5868

页数：6

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