An unusual gene dosage effect of p27kip1 in a mouse model of prostate cancer

被引：2

作者：

Abate-Shen, C

Shen, MM

机构：

[1] Rutgers State Univ, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Med, Piscataway, NJ 08854 USA

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Pediat, Piscataway, NJ 08854 USA

来源：

CELL CYCLE | 2005年 / 4卷 / 03期

关键词：

prostate cancer; p27(kip1); gene dosage; expression profiling; Cyclin D1; mouse models;

D O I：

10.4161/cc.4.3.1530

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Expression of the p27(kip1) cell cycle inhibitor is downregulated in a wide range of carcinomas, yet it is rarely inactivated completely. Our recent studies of a mouse model of prostate carcinogenesis have revealed that cancer progression is enhanced by a two-fold reduction in p27(kip1) gene dosage, but is unexpectedly inhibited by further decrease in p27(kip1) activity. This paradoxical finding may explain the unusual features of p27(kip1) downregulation in human cancer, and also suggests a potential route for therapeutic intervention.

引用

页码：426 / 428

页数：3

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