Complement receptors regulate lipopolysaccharide-induced T-cell stimulation

被引：19

作者：

Kaya, Z

Tretter, T

Schlichting, J

Leuschner, F

Afanasyeva, M

Katus, HA

Rose, NR

机构：

[1] Univ Heidelberg, Dept Internal Med 3, D-69120 Heidelberg, Germany

[2] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

[3] Johns Hopkins Med Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[4] Johns Hopkins Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

IMMUNOLOGY | 2005年 / 114卷 / 04期

关键词：

T lymphocytes; lipopolysaccharide; complement; cell surface molecules; cellular activation;

D O I：

10.1111/j.1365-2567.2004.02113.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Complement receptors type 1 and 2 (CR1 (CD35)/CR2 (CD21)) are known to enhance the adaptive immune response. In mice, CR1/CR2 are expressed on B cells, follicular dendritic cells, and activated granulocytes. Recently, we showed that a subset of CD44(high) and CD62L(low) T cells also expresses CR1 and CR2. We now report that CR1/CR2 are detectable on both CD4(+) and CD8(+) subsets of T cells. Lipopolysaccharide (LPS) from Gram-negative bacteria causes polyclonal activation of B cells and stimulation of macrophages and other antigen-presenting cells. We further demonstrate that LPS induced marked up-regulation of CD25 and CD69 on T cells from CR1/CR2 sufficient (Cr+/+), but significantly lower up-regulation on T cells from CR1/CR2 deficient (Cr-/-) mice. These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS.

引用

页码：493 / 498

页数：6

共 24 条

[11] A further link between innate and adaptive immunity:: C3 deposition on antigen-presenting cells enhances the proliferation of antigen-specific T cells [J].