One-Pot Formation of C-C and C-N Bonds through Palladium-Catalyzed Dual C-H Activation: Synthesis of Phenanthridinones

被引：317

作者：

Wang, Guan-Wu ^{[1
,2
]}

Yuan, Ting-Ting ^{[1
,2
]}

Li, Dan-Dan ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Soft Matter Chem, Joint Lab Green Synthet Chem, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 06期

基金：

中国国家自然科学基金;

关键词：

C-H activation; cross-coupling; heterocycles; palladium; phenanthridinones; ORTHO-ARYLATION; ROOM-TEMPERATURE; SP(2); AMINATION; ANILIDES; FUNCTIONALIZATION; CARBAZOLES; BENZAMIDES; AMIDATION; CHEMISTRY;

D O I：

10.1002/anie.201005874

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two cycles in one pot! The synthesis of biologically important phenanthridinones has been achieved by the one-pot formation of C-C and C-N bonds through a palladium-catalyzed dual C-H activation, which involves four bond ruptures and two bond formations (see scheme). The conversion of phenanthridinones into natural product like derivatives further demonstrates the utility of this synthetic achievement. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1380 / 1383

页数：4

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