Description of the OXA-23 β-Lactamase Gene Located Within Tn2007 in a Clinical Isolate of Acinetobacter baumannii from Spain

被引:14
作者
Guerrero-Lozano, Inmaculada [1 ]
Fernandez-Cuenca, Felipe [2 ]
Galan-Sanchez, Fatima [1 ]
Egea, Pilar [2 ]
Rodriguez-Iglesias, Manuel [1 ]
Pascual, Alvaro [2 ]
机构
[1] Puerta del Mar Univ Hosp, Clin Unit Clin Microbiol & Infect Dis, Cadiz 11009, Spain
[2] Virgen Macarena Univ Hosp, Clin Unit Infect Dis & Microbiol, Seville, Spain
关键词
CARBAPENEM-HYDROLYZING OXACILLINASE; MULTIPLEX PCR; EXPRESSION;
D O I
10.1089/mdr.2014.0155
中图分类号
R51 [传染病];
学科分类号
100201 [内科学];
摘要
A carbapenem-resistant Acinetobacter baumannii expressing bla(OXA-23) was recovered from an intensive care unit patient in a third-level hospital from Spain. Genetic analysis showed the association of this carbapenemase with the transposon Tn2007 located in a plasmid of 10 kb. The isolate was classified as ST-1. This strain has shown a potential ability to displace other endemic strains in the hospital and is the first reported identification of A. baumannii carrying bla(OXA-23) related to Tn2007 in Spain.
引用
收藏
页码:215 / 217
页数:3
相关论文
共 15 条
[1]
Genetic Basis of Multidrug Resistance in Acinetobacter baumannii Clinical Isolates at a Tertiary Medical Center in Pennsylvania [J].
Adams-Haduch, Jennifer M. ;
Paterson, David L. ;
Sidjabat, Hanna E. ;
Pasculle, Anthony W. ;
Potoski, Brian A. ;
Muto, Carlene A. ;
Harrison, Lee H. ;
Doi, Yohei .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (11) :3837-3843
[2]
CLSI, 2012, M100515 CLSI
[3]
Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii [J].
Corvec, Stephane ;
Poirel, Laurent ;
Naas, Thierry ;
Drugeon, Henri ;
Nordmann, Patrice .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (04) :1530-1533
[4]
Development of a set of multiplex PCR assays for the detection of genes encoding important β-lactamases in Enterobacteriaceae [J].
Dallenne, Caroline ;
Da Costa, Anaelle ;
Decre, Dominique ;
Favier, Christine ;
Arlet, Guillaume .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 (03) :490-495
[5]
Laboratory Detection of Enterobacteriaceae That Produce Carbapenemases [J].
Doyle, Diana ;
Peirano, Gisele ;
Lascols, Christine ;
Lloyd, Tracie ;
Church, Deirdre L. ;
Pitout, Johann D. D. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (12) :3877-3880
[6]
First Report of an OXA-23 Carbapenemase-Producing Acinetobacter baumannii Clinical Isolate Related to Tn2006 in Spain [J].
Espinal, P. ;
Macia, M. D. ;
Roca, I. ;
Gato, E. ;
Ruiz, E. ;
Fernandez-Cuenca, F. ;
Oliver, A. ;
Rodriguez-Bano, J. ;
Bou, G. ;
Tomas, M. ;
Vila, J. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (01) :589-591
[7]
OXA β-Lactamases [J].
Evans, Benjamin A. ;
Amyes, Sebastian G. B. .
CLINICAL MICROBIOLOGY REVIEWS, 2014, 27 (02) :241-263
[8]
In vitro activity of 18 antimicrobial agents against clinical isolates of Acinetobacter spp.: multicenter national study GEIH-REIPI-Ab 2010 [J].
Fernandez-Cuenca, Felipe ;
Tomas-Carmona, Maria ;
Caballero-Moyano, Francisco ;
Bou, German ;
Martinez-Martinez, Luis ;
Vila, Jordi ;
Pachon, Jeronimo ;
Miguel Cisneros, Jose ;
Rodriguez-Bano, Jesus ;
Pascual, Alvaro .
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2013, 31 (01) :4-9
[9]
Sequencing of the rpoB gene and flanking spacers for molecular identification of Acinetobacter species [J].
La Scola, B ;
Gundi, VAKB ;
Khamis, A ;
Raoult, D .
JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (03) :827-832
[10]
Nosocomial Outbreak of a Multiresistant Acinetobacter baumannii Expressing OXA-23 Carbapenemase in Spain [J].
Merino, Maria ;
Poza, Margarita ;
Roca, Ignasi ;
Jose Barba, Maria ;
Dolores Sousa, Maria ;
Vila, Jordi ;
Bou, German .
MICROBIAL DRUG RESISTANCE, 2014, 20 (04) :259-263