Asymmetric organocatalytic biginelli reactions:: A new approach to quickly access optically active 3,4-Dihydropyrimidin-2-(1H)-ones

被引:155
作者
Gong, Liu-Zhu [1 ]
Chen, Xiao-Hua
Xu, Xiao-Ying
机构
[1] Univ Sci & Technol China, Dept Chem, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China
[2] Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol, Chengdu 610041, Peoples R China
关键词
asymmetric catalysis; Biginelli reaction; multicomponent reactions; organocatalysis;
D O I
10.1002/chem.200700840
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The Biginelli reaction, known for over 100 years, is an important multicomponent reaction for accessing dihydropyrimidinones (DHPMs). The individual enantiomers of DHPMs exhibit different or even opposite pharmaceutical activities, which require synthetic methods to easily access the optically pure DHPMs. In recent decades, many efforts have focused on developing procedures for the preparation of optically active Biginelli products. In this article, we will summarize the developments in the synthetic methods to access optically active DHPMs with an emphasis on the recent advances in the asymmetric catalytic Biginelli reactions, along with concepts to design the organocatalytic asymmetric variants.
引用
收藏
页码:8920 / 8926
页数:7
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