Regulation of immunological homeostasis in the respiratory tract

被引:381
作者
Holt, Patrick G. [1 ]
Strickland, Deborah H. [1 ]
Wikstrom, Matthew E. [1 ]
Jahnsen, Frode L. [2 ,3 ]
机构
[1] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Nedlands, WA 6009, Australia
[2] Univ Oslo, LIIPAT, Ctr Immune Regulat, N-0027 Oslo, Norway
[3] Natl Hosp Norway, Div Pathol, N-0027 Oslo, Norway
关键词
D O I
10.1038/nri2236
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The respiratory tract has an approximate surface area of 70 m(2) in adult humans, which is in virtually direct contact with the outside environment. It contains a uniquely rich vascular bed containing a large pool of marginated T cells, and harbours a layer of single-cell-thick epithelial tissue through which re- oxygenation of blood must occur uninterrupted for survival. It is therefore not surprising that the respiratory tract is never more than a short step away from disaster. We have only a partial understanding of how immunological homeostasis is maintained in these tissues, but it is becoming clear that the immune system has evolved a range of specific mechanisms to deal with the unique problems encountered in this specialized microenvironment.
引用
收藏
页码:142 / 152
页数:11
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