Mechanisms of Tubulointerstitial Fibrosis

被引：745

作者：

Zeisberg, Michael ^{[1
]}

Neilson, Eric G. ^{[2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Div Matrix Biol, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[2] Vanderbilt Univ, Dept Med, Sch Med, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Dept Cell & Dev Biol, Nashville, TN 37232 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2010年 / 21卷 / 11期

关键词：

RENAL INTERSTITIAL FIBROSIS; CHRONIC KIDNEY-DISEASE; TO-MESENCHYMAL TRANSITION; TUBULAR EPITHELIAL-CELLS; NF-KAPPA-B; GROWTH-FACTOR-BETA; PLASMINOGEN-ACTIVATOR INHIBITOR-1; BONE MORPHOGENIC PROTEIN-7; MATRIX GENE-EXPRESSION; FIBROBLAST-LIKE CELLS;

D O I：

10.1681/ASN.2010080793

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in recent decades effective human treatment to directly halt or even reverse fibrosis remains elusive Here, we examine key features mediating the molecular and cellular basis of tubulointerstitial fibrosis and highlight new insights that may lead to novel therapies How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding

引用

页码：1819 / 1834

页数：16

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