Reversible metastatic pulmonary calcification in a patient with multiple myeloma

被引:20
作者
Weber, CK
Friedrich, JM
Merkle, E
Prummer, O
Hoffmeister, A
Mattfeldt, T
Frickhofen, N
机构
[1] UNIV ULM,DEPT RADIOL 1,D-89070 ULM,GERMANY
[2] UNIV ULM,DEPT MED 3,D-89070 ULM,GERMANY
[3] UNIV ULM,DEPT MED 2,D-89070 ULM,GERMANY
[4] UNIV ULM,DEPT PATHOL,D-89070 ULM,GERMANY
关键词
bisphosphonate; multiple myeloma; pulmonary calcification;
D O I
10.1007/s002770050181
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A-52-year-old patient presented with a 2-year history of multiple myeloma, recurrent episodes of hypercalcemia, and extensive bone involvement. She developed pulmonary infiltrates, initially misdiagnosed as interstitial pneumonia. High-resolution computed tomography and bone scintiscanning indicated pulmonary calcification, which was confirmed by a transbronchial biopsy. Cytostatic treatment of multiple myeloma in combination with repetitive i.v. administration of bisphosphonates over a period of 6 months led to a significant improvement of clinical symptoms. Regression of pulmonary infiltrates was demonstrated by chest radiograph and computed tomography. There are only a few reports on pulmonary calcification in patients with multiple myeloma; the condition was associated mostly with progressive disease, kidney failure, adult respiratory distress syndrome and bad prognosis. In our patient isolated calcification of the lungs without involvement of other organ systems was successfully treated. These findings suggest that interstitial pulmonary calcinosis in multiple myeloma can be reversed by normalization of serum calcium levels using bisphosphonates combined with cytostatic treatment.
引用
收藏
页码:329 / 332
页数:4
相关论文
共 23 条
  • [21] SEYMOUR JF, 1993, BLOOD, V82, P1383
  • [22] SPENCER H, 1977, PATHOLOGY LUNG, P685
  • [23] HYPERCALCEMIA, MONOCLONAL PROTEIN, AND OSTEOLYTIC BONE-LESIONS IN CHRONIC LYMPHOCYTIC-LEUKEMIA
    VANDECASTEELE, M
    VERHOEF, GEG
    DEMUYNCK, H
    ZACHEE, P
    BOOGAERTS, MA
    [J]. ANNALS OF HEMATOLOGY, 1994, 69 (02) : 79 - 80